International Review of Ophthalmology

Previous Articles     Next Articles

Research on exosomes and eye diseases

WU Jing1, YANG Chang-ping2, LIU Jin-rong1, LUO Yan1, XU Ying1, ZHONG Jia-ning1, WANG Hui3   

  1. 1.Gannan Medical University, Ganzhou Jiangxi 341000, China; 2. Department of Ophthalmology, Suichang People’s Hospital, Suichang Zhejiang 323300, China； 3. Department of Ophthalmology, The First Affiliated Hospital of Gannan Medical University, Ganzhou Jiangxi 341000, China
  • Received:2018-07-24 Online:2018-12-22 Published:2018-12-22
  • Contact: WANG Hui, Email: gyfywanghui@163.com
  • Supported by:

     Graduate Innovation Special Fund Project (YC2018-X0022）; The Funding of Ganzhou Experimental Animal Engineering Technology Research Center（202-4070）

Abstract:

Exosomes are microvesicles that contain proteins, lipids and RNAs. Exosomes are  secreted into the extracellular environment,which play an important role in cell-cell communication, immune regulation and maintenance of homeostasis.Exosomes are involved in occurrence and development of eye diseases such as glaucoma, age-related macular degeneration and corneal diseases. By detecting differentially expressed exosomes in aqueous humor, it is possible to find a potential biomarker for early diagnosis of glaucoma and retinal diseases. In addition, exosomes as intercellular communication mediators,  not only participate in the communication between transplanted cells and host cells, but also be used for targeting drug delivery, which has significant clinical importance for the treatment of human corneal transplantation and retinal diseases.(Int Rev Ophthalmol, 2018, 42:   388-392)